Russian Scientists Develop a Unique Drug for Treating Diabetes
Scientists from the N. N. Vorozhtsov Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences (Novosibirsk) are developing a new domestically produced medication designed to treat metabolic syndrome and related type II diabetes.
Project Overview:
Researchers have created a new molecule by combining the core of phenylpropanoic acid with terpenoids. Terpenoids are natural compounds commonly found in plants, conifer bark, and essential oils.
Mechanism of Action:
The new drug activates the PPAR-α and PPAR-γ receptors, which regulate fat and carbohydrate metabolism in the human body:
-
PPAR-α – lowers cholesterol levels and helps combat obesity;
-
PPAR-γ – reduces insulin resistance, making the body more sensitive to insulin.
Thus, the medication simultaneously affects both fat and sugar metabolism — a combined effect that most existing diabetes drugs do not possess.
Research Results:
In tests conducted on genetically modified mice, the new compound significantly reduced blood glucose and cholesterol levels without damaging liver enzymes. According to the results, the drug proved to be more effective and less toxic than several foreign analogues.
Advantages:
-
Made from natural, locally available raw materials in Russia (tree bark, conifer resin, and plant essential oils);
-
Has a cumulative (long-lasting) effect — its therapeutic impact continues over time, unlike many short-acting diabetes medications.
Current Stage:
The researchers have already obtained several patents. Together with the Institute of Cytology and Genetics (SB RAS), they are now studying how strongly the new compounds bind to receptors. The next phase is preparation for preclinical trials, which will require investment and production facilities.
Future Significance:
If the drug successfully passes all tests, it will become the third in the world and the first in Russia representative of the new class of medications known as “glitazars.” Such a drug could simultaneously help fight obesity, high blood pressure, elevated blood glucose, and cholesterol levels.
